After a failed alchemy experiment to revive their mother, brothers Edward and Alphonse suffer devastating consequences. Alphonse’s body disintegrates, and Edward loses a leg, sacrificing an arm to bind Alphonse’s soul to a suit of armor. Rescued by neighbor Pinako Rockbell and her granddaughter Winry, a prodigy in bio-mechanical engineering, Edward receives prosthetic limbs made from "automail," a durable metal. The brothers embark on a quest to find the Philosopher's Stone to restore their bodies. As Edward becomes the infamous "Fullmetal Alchemist," their journey uncovers a conspiracy that threatens the world’s future.